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    • 专利摘要:
    MEDICAL DEVICE HAVING A DRUM, A RETRACTABLE NEEDLE, A NEEDLE RETRACTION UNIT AND A Piston. A medical device, having a drum, a retractable needle, a needle retraction unit and a plunger, the needle retraction unit including the and being retained within the drum prior to retraction, at least in part, by a retaining member contacting the drum and an elastomeric film that seals a retraction cavity within the plunger before retracting the needle, the retaining member and the plunger seal cooperating with an inner wall of the drum, to provide a sealed liquid containment chamber within the device.
    公开号:BR112012033775B1
    申请号:R112012033775-0
    申请日:2011-06-30
    公开日:2020-07-28
    发明作者:Thomas J. Shaw；Ni Zhu
    申请人:Retractable Technologies, Inc；Thomas J. Shaw；
    IPC主号:
    专利说明:

    TECHNICAL FIELD
    [0001] This invention relates to medical devices having needles that are retractable after use, to reduce the likelihood of reuse, needle stick injuries and accidental contamination of healthcare workers and patients, especially by the transmission of pathogens carried by body fluids. More particularly, the invention relates to a medical device having an elastomeric retaining ring and an elastomeric plunger seal, movable on the plunger, which cooperates to provide smoother operation and to significantly reduce the pressure that must be applied by the user to collect the needle. BACKGROUND OF THE INVENTION
    [0002] In the past, clinicians have sometimes complained about the magnitude of the thumb strength (sometimes called “retraction force”, “activation force” or “total force”) that is needed to initiate syringe needle retraction having retractable needles. When using conventional syringes having needles that are retracted by expanding a compressed spring, additional thumb force is typically applied axially to the back of the plunger cable following injection to initiate needle retraction. The magnitude of the thumb force that is required depends on the structure and operation of each particular syringe. A portion of the required thumb force is attributable to the force required to break, break, remove or move the cover over the opening within a retraction cavity within the plunger cable. Another part of the required thumb force is attributable to the force needed to release any structure that is holding the compression spring. If the required thumb strength is too great, especially for clinicians with small hands, it may be difficult to retract the needle after an injection. This can cause the user to move or twist the syringe while the needle is still inside the patient, in order to gain more leverage. Also, unless the structural elements of the device are configured so that the thumb force can be applied smoothly, in order to open the retraction cavity and release the compressed spring without pulling or abrupt movement before retraction.
    [0003] Some prior art syringes have used a substantially rigid plug or barrier to block entry to the retraction cavity within the plunger cable prior to retraction, however the force required to dislodge or move the plug, or to fracture the barrier substantially rigid, it also increased the required thumb strength. Other prior art syringes used an axially fixed plunger seal, having a rubber part covering the opening for the retraction cavity, in combination with a two-part plunger cable, in which an inner member had to be moved beyond a stopper to advance a cutter that cuts the covering part, thereby also increasing the required thumb strength. In such cases, the force required to dislodge a plug, fracture a barrier or move a plunger section in addition to a stopper not only increased the thumb force required to initiate the retraction but also caused the syringe to shake or move abruptly before needle retraction.
    [0004] US 5,053,010 (McGary) describes a syringe having a retractable needle and a plunger with an axially slidable plunger seal, having a cross-section of film that seals the opening within the plunger retraction cavity prior to retraction. This syringe has a cutting tool arranged at the tip of the plunger extending forward, which cuts through both the transverse film through the opening to the retraction cavity and the other tongue extending circumferentially, which holds the needle retainer in the drum wall. Due to the cutter positioned behind the transversal film, there is a risk of premature rupture of the film during injection, which is not desirable because the remaining part of the medicine inside the syringe could flow back into the retraction cavity, instead of into the patient.
    [0005] U.S. 5,064,419 (Gaarde) describes a syringe having a retractable needle and a piston with a piston pad which is confined to prevent axial movement relative to the piston. Fig. 3 describes a thin membrane attached to the piston gasket. The thin membrane seals the cavity inside the piston, until the flat head of the needle holder punctures or destroys the membrane for retraction. The needle holder is held in position by the closed base end of a drum section, which is disposed within the spring retainer.
    [0006] U.S. 5,180,369 (Dysarz) describes a syringe having a retractable needle and a gasket disposed between the plunger and the barrel, which is axially slidable over the plunger. This syringe has a tear-off plate that seals the opening into the retraction cavity inside the plunger prior to retraction. The needle holder is held in position before retraction by a breakable plate and a breakable ring, each of which requires an additional gasket to provide a fluid seal.
    [0007] U.S. 5,180,370 (Gillespie) describes a syringe having a retractable needle and an annular seal ring, which provides a fluid seal between the plunger and the barrel. The annular seal ring does not appear to be confined to prevent axial movement relative to the plunger, however it does not appear to slide axially in relation to the plunger during use. The plunger has a hollow chamber that is sealed from the inside of the drum by a resilient breakable cover.
    [0008] US 5,201,710 (Caselli) describes a syringe having a retractable needle held by a needle holder having a head with a sharp part shaped like a crown with a sharp edge that first folds and then breaks a diaphragm connected to a piston sealing element, which is confined to prevent axial slippage in relation to the piston cylinder.
    [0009] US 5,578,011 (Shaw) describes a syringe having a retractable needle and an elastomeric friction ring to retain the needle holder within the barrel and to provide a fluid seal between the drum wall and the needle holder . This syringe has a plunger seal that is confined against axial sliding along the plunger, and an elastomeric plug that provides a release seal within the opening facing the retraction cavity within the plunger.
    [00010] US 6,015,438 (Shaw) describes a syringe having a retractable needle, an annular retaining member for retaining the needle holder within the barrel and a plunger seal disposed between the plunger and the barrel that is axially slidable along plunger for retraction. This syringe has a removable plug, which seals the opening inside the retraction cavity inside the plunger before retraction.
    [00011] US 6,994,690 (Kiehne) and US 7,544,182 (Kiehne) describe syringes having a retractable needle and a tapered extension over the inner part of the needle holder head, which protrudes backwards to break or puncture a breakable part of a fixed plunger seal when the plunger is advanced against the needle holder. However, in these syringes, the plunger seal is axially confined and cannot slide backwards relative to the front of the plunger to stretch the fragile part tautly on the side of the barrel when the plunger contacts the needle holder.
    [00012] A medical device, having a retractable needle, is therefore necessary, that it can be operated smoothly to initiate the retraction of the needle and that reduces the thumb force necessary to initiate the retraction. SUMMARY OF THE INVENTION
    [00013] The medical devices of the invention desirably comprise a drum, a plunger slidably engaging the drum and a needle retraction unit that can be selectively activated to retract the needle by moving the plunger forward relative to the drum. The needle retraction unit may desirably comprise an elastomeric retaining ring, which contacts an inner wall of the drum, to help create a liquid seal between a needle holder and the inner wall of the drum that helps retain a retraction spring. compression needle before needle retraction. The plunger desirably comprises an elastomeric seal with an annular body part and a transverse elastomeric film part. The annular body can act as a liquid seal between the plunger and the drum, and the transverse film part can seal an opening within a retraction cavity disposed within the plunger prior to retraction.
    [00014] The annular body part of the plunger seal can be attached to the front part of the plunger in such a way that the body part is axially movable in relation to the external wall of the plunger, to stretch and thin the transverse film through the opening into the retraction cavity, without prematurely breaking the transverse film part to initiate the retraction of the needle. The annular end facing the front of the plunger, disposed behind the transverse elastomeric film, is preferably configured so as not to cut the elastomeric film when the film is stretched through the opening into the retraction cavity before retraction, but can be configured to exert a force that is uniform or evenly distributed around the circumference of the retaining ring, as desired. An unevenly distributed force can reduce the force required to initiate the movement of the retaining ring in relation to the drum prior to retraction. The plunger force is typically applied to the retainer ring through that part of the plunger seal that covers the end of the front end of the plunger cable, although a part of the plunger cable can contact the retainer ring directly in some cases, such as, for example, the elastomeric film breaks before contacting the retaining ring.
    [00015] Before retraction, the needle and needle holder parts of the needle retraction unit can be propelled backwards by a compressed spring. The propensity force is desirably slightly less than a holding force exerted on the needle support part by a retaining member that establishes a liquid seal between the inner side of the drum and the needle holder and that holds the tip forward of the needle holder in a position projecting forward in relation to the drum until retraction. When the plunger is fully compressed within the barrel, the body part of the elastomeric plunger seal can be pushed back in relation to the plunger and the transverse film part of the elastomeric plunger seal can be stretched, tuned and eventually penetrated, punctured or ruptured by a part projecting behind the needle holder when the retaining member is displaced by the plunger to release the holding force exerted on the needle holder by the retaining member and the inner wall of the drum. This, in turn, can allow the bias force of the compressed spring to propel the needle holder, spring and needle back through the broken film of the elastomeric plunger seal and into the retraction cavity. When the plunger is fully compressed within the barrel, a thumb cap on the rear of the plunger can be housed within a cylindrical collar on the rear of the barrel, in order to make the thumb cap substantially non-clingable for reuse.
    [00016] The use of an elastomeric retaining ring, in combination with a plunger seal having a body part that is axially movable backwards along the barrel and an elastomeric film part that can be stretched and tuned by such axial movement to behind the body part before retraction, it is believed to provide smoother retraction and substantially reduce the thumb force that must be applied by a user to initiate needle retraction. Smoother operation and less thumb strength required in turn is believed to reduce the movement of the needle tip forward or laterally within a patient before retraction, to promote the use of devices having retractable needles by clinicians, and to thereby reducing the incidence of unwanted needle stick injuries and the associated spread of pathogens contained in the blood, due to inadvertent contact contamination. BRIEF DESCRIPTION OF THE DRAWINGS
    [00017] The apparatus of the invention is further described and explained in relation to the following drawings, in which:
    [00018] Fig. 1 is a perspective view of an embodiment of the medical device of the invention;
    [00019] Fig. 2 is an exploded perspective view of the medical device of Fig. 1;
    [00020] Fig. 3 is a vertical elevation view in enlarged cross section, taken along line 3-3 of Fig. 1, where the needle is in a position of use projecting forward;
    [00021] Fig. 4 is an enlarged detailed view, taken from Fig. 3, but showing the elastomeric seal through the front of the retraction cavity being extended by the head projecting to the front of the needle holder, when the tip of plunger moves forward inside the drum;
    [00022] Fig. 5 is a cross-sectional elevation view of the medical device of Fig. 3, in which the needle is in its fully retracted position;
    [00023] Fig. 6 is a detailed enlarged cross-sectional view of the front of a plunger as shown in Fig. 3, with the elastomeric seal arranged in the position shown in Fig. 3;
    [00024] Fig. 7 is a detailed enlarged cross-sectional view of the front of a plunger as shown in Fig. 5, with the elastomeric plunger seal moved backwards from the position shown in Figs. 3 and 6, with the part of the plunger seal that previously extended through the end of the plunger having broken and contracted to the sides of the end of the plunger extending forward.
    [00025] Fig. 8 is a base plan view of the medical device of Fig. 1;
    [00026] Fig. 9 is a top plan view of the medical device of Fig. 1;
    [00027] Fig. 10 is a horizontal view of an enlarged cross section, partially detached, of another embodiment of the medical device of the invention, in which the needle is in a position of use projecting forward;
    [00028] Fig. 11 is an enlarged detailed view, taken as indicated in Fig. 10;
    [00029] Fig. 12 is an enlarged horizontal cross-sectional view of the medical device of Fig. 10, but rotated 90 degrees around the longitudinal geometric axis of the device, in which the plunger is fully compressed within the barrel and where needle is fully retracted;
    [00030] Fig-13 is an inclined elevation view of another embodiment of the medical device of the invention;
    [00031] Fig-14 is an exploded perspective view of the medical device of Fig. 13;
    [00032] Fig-15 is a horizontal elevation view of an enlarged cross section, taken along line 3 -3 of Fig. 1, in which the needle is in a position of use projecting forward and is covered by a protective cover,
    [00033] Fig-16 is a left side elevation view in cross section along line 16 -16 of Fig. 15;
    [00034] Fig. 17 is a horizontal elevation view of an enlarged cross section, in which the plunger is fully compressed within the barrel and in which the needle is fully retracted;
    [00035] Fig. 18 is a cross-section elevation view of another embodiment of the medical device of the invention, when arranged in a horizontal position, in which the piston cable has a stepped front;
    [00036] Fig-19 is a left side elevation view of the entire (not in cross section) medical device of Fig. 18;
    [00037] Fig-20 is a right side elevation view of the entire (not in cross section) medical device of Fig. 18;
    [00038] Fig-21 is a cross-section elevation view of the Fig. 21 embodiment, in which the head protruding behind the needle holder has engaged and stretched or stretched the elastomeric film of the plunger seal to behind and where the part extending further back the plunger cable, covered by the elastomeric film of the plunger seal, is contacting the retaining member before the needle retracts;
    [00039] Fig-22 is a cross-section elevation view of the embodiment of Fig. 21, following the retraction of the needle;
    [00040] Fig-23 is an enlarged detailed view, taken from Fig. 18 that best illustrates the staggered front of the plunger part of the subject medical device;
    [00041] Fig. 24 is a detailed cross-sectional view similar to that shown in Fig. 23, but showing an alternative embodiment of the invention, employing a differently configured piston seal and the piston being moved backwards relative to the drum as it would be, for example, during aspiration of fluid into the device;
    [00042] Fig-25 is a detailed cross-sectional view similar to that shown in Fig-24, but with the plunger being moved forward in relation to the drum as it would be, for example, during fluid infusion in a device patient ;
    [00043] Fig. 26 is a front elevation view of the alternative plunger seal of Figs. 24 and 25, but shown in a relaxed position before being installed on a plunger cable;
    [00044] Fig. 27 is a side elevation view of the plunger seal of Fig. 26; and
    [00045] Fig. 28 is an enlarged cross-section elevation view, taken along line 28 -28 in Fig. 26. DESCRIPTION OF THE PREFERRED EMBODIMENTS
    [00046] An embodiment of the medical device of the invention is described and explained in relation to Figs. 1-9, in which the syringe 10 comprises, as its main parts, the barrel 24, a needle retraction unit installed in the front of the barrel 24 and plunger unit 12 that slidably fits into an opening at the rear of the barrel . The needle retraction unit comprises needle holder 18, needle 20, compression spring 22 and retainer member 16. A removable needle cover, which protects the needle tip 20 during packaging, shipping and storage, is not shown in Figs. 1-9, but a suitable needle cover is shown, for example, in relation to another embodiment of the invention, such as molded plastic needle cover 206 in Figures 13-14.
    [00047] The drum 24 comprises the tubular body 26 with flanges extending radially opposite 28, providing contact surface for the index and middle fingers of a user, a collar of larger diameter 30 disposed behind the flanges 28, a collar facing of smaller diameter, optionally comprising a plurality of arched, spaced, longitudinally directed ribs 98, which provides an accommodation surface for a removable needle cover, and a nose extending forward, tapered, 76, having an open end through the which the front tip 70 of the needle holder 18 desirably protrudes when the needle retraction unit is accommodated within the barrel 24. With reference to Fig. 2, the collar 30 is optionally provided with one or more notches 29, so that collar 30 can expand slightly if necessary so that collar 30 receives end cap 34 of plunger unit 12. The provision of notches 29 allows for the use of more str tolerances between the inner diameter of the collar 30 and the outer diameter of the end cap 34, to ensure a precise fit between the two parts and to make the end plunger cap 34 less grasping after injection and retraction, to help prevent reuse syringe 10.
    [00048] The plunger unit 12 includes the tubular body 38, with an end cap of larger diameter 34, a plurality of optional ribs, arched spaced, extending longitudinally 60, arranged around the body 38, annular high face 42 , annular positioning ring 44, front end 94 and elastomeric plunger seal 14. The plunger seal 14 is preferable and unitarily molded of a compressible rubber material and comprises an annular body part and a cross-section film. The annular body part of the plunger seal 14 desirably comprises outwardly axially spaced, annular projections 48, 50, 52, separated by annular recesses 54, 47, respectively, and an inward annular recess 46. It will be observed by those skilled in the art, when reading this description, that the annular edge or flange disposed forward, as exemplified, for example, by the annular edge 48 of Fig. 6, performs the primary sealing function, while the second annular flange away, like the edge 50 of Fig. 6, it mainly serves to align the plunger seal inside the drum.
    [00049] With reference to Figs. 2 -3 and 6, the annular recess 46 is deep enough to cooperatively receive the sized and shaped annular positioning ring 44 when the piston seal 14 is attached to the tubular body 38 of the piston unit 12 and has a front wall sloping and a square rear wall. When the elastomeric plunger seal 14 is attached to the front end of the tubular body 38, the open rear end is pressed onto the front end 94 and the annular positioning ring 44, so that the part facing inward of the piston 14, at the rear end of the annular recess 46, slides upwards on the sloping front face of the annular positioning ring 44 and along the top of the annular ring 44, until the square shoulder, facing forward at the rear of the ring ring 46, fall on the square ledge behind the positioning ring 44. When the body part of the piston seal 14 reaches the position shown in Figs. 3 and 6, the transverse film portion 58 of the plunger seal 14 blocks and seals the opening of the front end of the tubular body 38, which is defined by the blunt annular surface of the front end 94. As used herein, the expression “surface blunt ”is intended to differentiate a surface having edges that do not cut from a surface having edges that can cut, and it should be noted by those skilled in the art, when reading this description, that an injection molded plunger body or cable will have a front end with a small radius at each edge, which will prevent the plunger tip from cutting the transverse elastomeric film, particularly when the shear force, exerted on the film by the tip, is spread evenly around the circumference of the film when the film is stretched and thinned by moving the tubular body back over the plunger.
    [00050] With reference to Fig. 2, the front end 94 of the tubular body 38 can define a single plane, which is perpendicular to the longitudinal geometric axis 55 through the syringe 10 or can be otherwise configured so that at least one part of the front end 94 advances ahead of the rest of the front end 94, when the plunger 12 is advanced into the barrel 24, to facilitate retraction, as previously described, for example, in US 6,572,584. It will be observed, whenever the plunger 12 is advanced into the barrel 24 to facilitate retraction, that the front end 94 of the plunger 12 is desirably covered by the plunger seal 14, thereby causing the front end 94 to contact the member retainer 16 indirectly through the piston seal 14, or directly if the transverse film portion 58 breaks first.
    [00051] The annular recess 46 of the annular body may be of sufficient axial length to allow the plunger seal 14 to slide backwards on the outer side of the tubular body 38 and provide a predetermined range of displacement between the position as shown in Figs. 3 and 6 and the position as shown in Figs. 5 and 7. When the body part of the piston seal 14 is in its most rear position relative to the tubular body 38, the annular surface 86 at the rear of the piston seal 14 can contact the annular shoulder facing forward 88 of the body tubular 38 and the inclined front wall of the annular recess 46 can also contact the inclined front surface of the ring by positioning itself annular 44.
    [00052] With reference to Figs. 2 and 3, the needle retraction unit can be mounted by applying the retaining member 16 to the larger diameter section 62 of the needle holder 18, inserting the front tip 70 and the elongated tubular body part 74 through the spring of compression 22 and then inserting the retaining member 16, needle holder 18 and spring 22 into the rear of the drum 24 and advancing them forward into the drum 24, until the front end 70 extends through the opening narrow 63 in front of the drum 24 and the forward facing annular shoulder 68 of the needle holder 18 is blocked by a cooperative rear facing annular shoulder 65 within the nose front end 76 of the drum 24. At the same time, the spring 22 is compressed between the underside of the larger diameter section 62 of the needle holder 18 and the annular shoulder 65 inside the nose 76. When the needle retraction unit is in the position shown in Fig. 3, within the surface 80 of the limb retainer 16, provides a seal for liquid between the retaining member 16 and the outwardly facing surface of the larger diameter section 62 of the needle holder 18 and the outer surface 82 of the retaining member 16 provides a seal for liquid against the inner side of the tubular body 26 of the barrel 24. The blunt, rear-facing end of the needle 20 can then be inserted into the tip extending forward 70 of the needle holder 18 and placed in position or otherwise secured by known methods similarly effective, thereby protecting the tip the insertion through the rear of the barrel 24. When the syringe 10 is assembled in this way, fluid communication is established from the needle tip 20 extending forward, chamfered, through the chamber 84 extending axially and transversely extending through the paths 65 of the needle holder 18 and into the fluid chamber 90 of the drum 24.
    [00053] When the plunger unit 12 is advanced into the barrel 24 during an injection, typically pressing a thumb against the thumb cap 36 of the end cap 34, while simultaneously exerting back pressure against the edges 42 arranged in around the forward facing surfaces of the opposing flanges 28, the plunger unit 12 reaches a point where the transverse film 58 contacts and flexes around the tip projecting back, rounded, 64 from the needle holder 18, as seen in Fig. 4. This causes the fluid remaining inside the chamber 90 of the syringe 10 to be forced into the fluid paths 65, when the annular front surface 100, of the body part of the elastomeric plunger seal 14, continues downward to a point where the annular surface 100 is accommodated against the angled surface 102. When this happens, the pressure exerted by the angled surface 102 against the annular surface 100 causes the annular body part of elastomeric seal 14 moves, slides, displaces or extends backwards with respect to annular positioning ring 44 of tubular body 38. When the annular body part of elastomeric seal 14 moves to behind the tubular body 38 of the plunger 12, the transverse film part 58, preferably being integrally formed with the annular body part, is stretched tautly by the tip projecting back 64 of the needle holder 18. In this embodiment of the invention, the front tip 94 nor the rear projecting tip 64 of the needle holder 18 is sharp enough to function as a cutter, prior to the occasion when the projecting tip 64 punctures or punctures the extended transverse film 58 .
    [00054] Continued application of the thumb force to the thumb cap 36 of the plunger unit 12, which in practice occurs as a smooth, continuous movement, causes the tip protruding back 64 from the needle holder 18 to break the cross-section 58 and allow the front end 94 of the plunger body 38 to contact, directly or indirectly (if the cross-section film 58 breaks before contact is made), and push the retaining member 16 forward out of the section large diameter 62 of the needle holder 18, thereby allowing the compressed spring 22 to push the needle holder 18 and at least part of the needle 20 back into the retraction cavity 40, inside the plunger body 38, with the beveled front end of needle 20 also being pulled in and confined within drum 24. Referring to Figs. 4, 5 and 7, because the part of the broken transverse film 58 is desirably elastomeric and because it has been tightly stretched through the opening defined by the front end 94 of the plunger body 38, before rupture, remaining from the transverse film they can contract out of the way of the front tip 94 when it contacts the retaining member 16, and also out of the way of the needle holder 18 and needle 20, when they are projected backward by spring 22, to avoid delay during retraction. As a result, with reference to Figs. 5 and 7, the needle 20 is retracted into the barrel 24, the base of the relaxed spring 22 remains seated on the annular shoulder 65 inside the nose 76 and the annular rear surface 86 of the annular body part of the elastomeric plunger seal 14 moves to the annular shoulder 88 of the tubular body 38 of the plunger unit 12. After retraction, the spring end 22 extending forward does not necessarily have to remain seated on the annular shoulder 65 within the nose 76.
    [00055] Figs. 10-12 represent another embodiment of the invention, in which syringe 110 is made similar to but slightly different from syringe 10, as discussed above. A readily observable difference in syringe 110 is vent hole 116, which is provided through the wall of tubular body 114 of the plunger unit, to ventilate the retraction cavity 150 when needle holder 118 and needle 122 are propelled backward during retraction. Another readily observable difference from syringe 110 is the configuration of needle holder 118. Unlike needle holder 18, needle holder 118 has two opposing, relatively pointed cusps, 140, 142, which cooperate to puncture the transverse film portion 148 of the sliding elastomeric plunger seal 144. Because the cusps are opposite and do not extend circumferentially around the head extending behind the needle holder 118, the medicine can enter the centrally arranged hole 166 of the needle holder 118 and no transverse liquid flow path, such as the fluid paths 65 of the needle holder 118, would be necessary to reduce the amount of empty space or "dead space" that could otherwise be present. Except for these observed differences, the structure, assembly and operation of the syringe 110 of the invention are substantially the same as described in relation to syringe 10.
    [00056] With reference to Fig. 10, the syringe 110 comprises the barrel 112, into which the plunger 114 is inserted in a sealing fit, this sealing fit being provided by a rubbery plunger seal, unitly molded, comprising an annular body 114 and a transverse elastomeric film 148. When the annular body 144 contacts the inclined shoulder 155, when the plunger 114 is advanced into the barrel 112 before retracting the needle, the annular body 144 can move backwards along the annular surface 146 of the plunger 114, thereby stretching the elastomeric film 148. The retraction cavity 150, disposed within the plunger 114, has an open front end, which is sealed by the elastomeric film 148 and a closed rear end, which is blocked by the end cap 162. When the plunger 114 is fully lowered into the drum 112, during and after an injection, the end cap 162 is desirably housed within the annular recess 164 of the drum collar, making the end cap 162 less gripable for subsequent removal of the piston 114 from the drum 112.
    [00057] At the front of the drum 112, the needle holder 118 is seated in a position where the annular shoulder 15 fits on the inside of the drum 112, when the front tip 158 of the needle holder 118 extends forward to out of an opening at the front end of the drum 112. With reference to Figs. 10 and 11, the needle 122 is attached to the needle holder 118 within the centrally disposed hole 166 of the elongated front section 120. The end extending forward of the retraction spring 124 is also seated against an annular shoulder in front of the tip of the drum 112 and the rear-facing end of compressed spring 124 contacts and exerts a biasing force against an annular shoulder 128 facing forward of a larger diameter section 126 of needle holder 118. Needle holder 118 is retained in position before retraction by the compressed elastomeric retaining ring 130, which also provides a fluid tight seal between the needle holder 118 and the inner wall of the drum 112. The annular space 154 is slidably provided in front of the retainer ring 130, to facilitate retraction as discussed below in relation to Fig. 12. Referring again to Fig. 10, a sealed liquid containment chamber 147 is thereby provided within the barrel 112, between the retaining ring 130 and annular body 114 and elastomeric film 148 of the plunger seal, with the only remaining fluid path being through the needle holder bore 118 and needle 122.
    [00058] With reference to Figs. 10 and, by comparison, 12, when the plunger 114 is advanced fully inside the barrel 112 by the pressure of the user's thumb following the injection, the structures projecting backwards 140, 142, best seen in Fig. 11, contact and they stretch back or dislodge the elastomeric film 148. When this occurs, the annular body of the plunger 114 advances against the opposite annular shoulder 155 inside the barrel 112, which causes the annular body 144 to move backwards, stretching the film elastomeric 148 more taut when the plunger 114 continues to move forward relative to the drum 112. When the front end of the plunger, acting through the plunger seal, contacts and pushes the retaining ring 130 forward into the space 154, the projections 140, 142 break the elastomeric film 148 and the retaining ring 130 releases the needle holder 118 to retract the needle 122 into the barrel 112, when the needle holder 118 is pushed into the cavity d and retraction 150. Following retraction, as seen in Fig. 12 compared to Fig. 11, the annular body 144 of the plunger seal is displaced towards the annular wall 145 of the plunger 114. The retaining ring 130 remains in the space ring 154, spring 124 is relaxed and needle holder 118 and needle 122 are all arranged within the retraction cavity of plunger 114. As shown in Fig. 12, needle holder 118 and needle 122 are rotated 90 degrees from the position shown in Figs. Well, to better illustrate flanges 164 and projection 140.
    [00059] Another embodiment of the invention is described and explained in relation to syringe 200, as shown in Figs. 13 -17. Fig. 13 represents syringe 200 as it could be packaged, shipped and stored. Syringe 200 preferably comprises barrel 202, plunger 204 inserted into and slidably engaging the inner wall of barrel 202, and protective cover 206 covering needle 236, as seen in Fig. 14. As previously seen with respect to syringe 10 , needle cover 206 is shown in Figs. 13-15 to illustrate how such a cover can be constructed and releasably attached to the front end of drum 202 to protect needle 236 from being accidentally blunted or folded prior to use. The needle cover 206 is desirably loosely attached to the front of the drum 202 by friction fitting, although it is noted that such friction fitting can be implemented in various ways known to those skilled in the art. For example, frictional engagement can be achieved using an annular pressure ring, cooperatively tapered conical or ribbed surfaces, threads or the like, which are disposed within the lid or on the nose portion of drum 202, or both. By providing a lid that has a larger opening at the end facing drum 202, it is possible to use the lid as a guide during assembly. According to a preferred embodiment of the invention, the front end of the needle cover 206 is opened to allow the cap to breathe and to allow the mold core pins to be pulled from each end. When used with syringes 202 having separable needles, the cap can even be used as a wrench, to help attach a threaded needle tip to the front end of a needle holder, or to mount a front end accessory comprising a needle in the drum.
    [00060] Referring next to Fig. 14, the plunger 204 of the syringe 200 further comprises a molded end cap 210, having a removable insert 208; a plurality of circumferentially spaced ribs, extending axially 212, to provide stiffness to the plunger 204 and to minimize possible frictional contact between the plunger 204 and the barrel 202; a plunger seal, having an annular body part 220, which can be seated around the tip of the plunger 204 on the annular boss 214 and can slide back through the recess 218, towards the shoulder 216 of the plunger 204, to facilitate retraction. The plunger seal also has a cross-section of elastomeric film 242 (Fig. 15), which provides a seal on the open end facing the front of plunger 204 prior to retraction. The annular boss 214 on the outer side of the plunger 204 is received within the cooperating annular recess 240 of the annular body 220 and provides sufficient holding force to prevent the plunger 204 from pulling out the plunger seal when the plunger 204 is pulled back into the drum 202 during suction.
    [00061] The syringe needle retraction unit 200, as shown in Fig. 14, comprises a needle holder having two parts that are screwed together, to facilitate changing the needles if necessary. The needle base 234 has a male threaded section, which is releasably insertable with the female threaded front end 228 of the elongated body section 226, under the larger diameter head section 224, which further comprises at least one projection facing back 246, as described in more detail with reference to Fig. 15. During assembly of the syringe 200, the elastomeric retaining ring 222 is slightly stretched so that it can be applied over the head portion 224 of the needle holder. The front end portion 228 of the needle holder is inserted into spring 256, which is compressed around body section 226 and inserted into barrel 202, until both body section 226 and spring 256 are seated within the drum 202 and retainer ring 222 is pressed sufficiently against the inner side of the drum 202, to prevent the spring 256 from expanding and to establish a seal for liquid between the head portion 224 of the needle holder and the inner wall of the drum 202 In the embodiment shown (Fig. 15), a small annular pump 272 is also provided on the inner wall of the drum 202, to provide additional friction support and fit between the retaining ring 222 and the inner wall of the drum 202. In Following the installation of the needle retraction unit, the assembled plunger, with the plunger seal 220 attached, can then be inserted into the open collar at the rear of the 202 barrel, to slide into the inner wall.
    [00062] The needle base 234, with or without the needle 236 already attached, is then screwed into place with the front end 228 of the body section 226 of the needle holder seated inside the barrel 202. Depending on the internal configuration of the cover necessary 206, it can possibly be used as a wrench to rotate the needle base 234 to fit the threads with those of the body section 226. At the same time, the rear facing open end 261 of the needle cover 206 can be placed around the nose extending in front of the drum 202, to help align the needle base 234 and the threaded end 228 of the body section 226, to obtain an appropriate threaded fit. If desired, it will be appreciated that the needle base 234 can also be secured before inserting the plunger 204 into the barrel 202.
    [00063] Figs. 15 -16 represent in more detail the internal structure of the mounted syringe 200. The barrel 202 comprises opposing flanges 232 near the rear end, which provide gripping surfaces for the user's fingers and prevent the syringe 200 from rolling off a surface of Support. The rear extending collar 230 is desirably provided behind the flanges 232 and comprises the recess 238 adjacent to the open rear end of the drum 202. The recess 238 is desirably sized and positioned so that the perimeter of the plunger end cap 210 is arranged in close association with and, preferably, nested within the collar 230, following the retraction of the needle. The insert 208 is provided with the vent 209 for the retraction cavity 244 and also facilitates the insertion and removal of a tap during molding.
    [00064] In the embodiment shown in Fig. 15, a small annular pressure ring 258, comprising a cooperatively dimensioned and aligned boss and recess, disposed within the front section 260 of the needle cover 206, close to the front of the base. needle 234, is provided to provide friction fit between needle cover 206 and syringe 200. This allows the side cover wall 206 to be spaced slightly beyond the nose 268 of drum 202. Opening 262 is desirably provided at the end of front of the front section 260, but sterility is not adversely affected because syringe 200 is stored in a sterile wrap until the time of use, when cover 206 is removed in any case.
    [00065] Needle 236 is desirably attached to needle base 234 by glue (or by another similarly effective fixation method) disposed in annular recess 254, and needle base 234 is reliably attached to the inner side of the needle holder body 226 by cooperating threads 264, 266. The retraction spring 256 is compressed into the annular space between the nose 268 and the needle support body 226. The spring 256 is retained in compression by the retaining ring 222 disposed around the support head of needle 224. The projection 246 facing backwards at the rear of the needle holder is centrally arranged and comprises a plurality of inclined circumferentially spaced supports, providing lateral support. Rounding the tip of the projection 246 allows the elastomeric film 242 to be stretched backwards by a greater distance than would otherwise be possible before breaking during the retraction. The cross flow channel 248 desirably provides fluid communication with the needle holder bore 250 to allow fluid to flow into or out of the liquid containment chamber 270 of the barrel 202 through the needle 236. The projection 246 , elastomeric film 242 and transverse flow channel 248 cooperate to provide greater utilization of the volume within the liquid containment chamber 270.
    [00066] With reference now to Fig. 15, in relation to Fig. 17, when plunger 204 advances forward towards projection 246, the projection contacts elastomeric film 242, causing it to stretch backward to inside the retraction cavity, while the front part of the annular body 220 of the piston seal contacts the inclined annular shoulder 274 of the barrel 202. When the piston advance continues, the annular body 220 slides back until it contacts against the annular shoulder 216 plunger 204, which also stretches and sharpens the elastomeric film 242 to the projection break point 246. It should be noted when reading this description, that the use of a rear-facing projection, even one that does not form a tip or edge sharp, it is likely to break the elastomeric film in the region of contact between the projection and the film before the film separates from the annular body around the circumference of the plunger tip. This is believed to be because the stretching force exerted on the film by the annular body is spread evenly around the circumference, while the force exerted on the film by the projection is concentrated within a much smaller area.
    [00067] When the plunger seal moves back over the plunger 204, the front end of the plunger, acting through the plunger seal, contacts the retaining ring 222 directly or indirectly and begins to push it into the space ring 252. The elastomeric film 242 desirably breaks just before the needle holder is released by the retaining ring 222. When the needle holder is released, the spring 256 drives the needle holder backwards through the opening in front of the retraction cavity 244 of plunger 204, which is formed as the annular skirt that was previously elastomeric film 242, can respond sharply after elastomeric film 242 is broken by projection 246. Once elastomeric film 242 responds sharply following penetration by projection 246, the remnants of the film may, in some cases, remain arranged between the front end of the plunger and the retaining ring 222. In other cases, the front end of the plunger can directly contact retaining ring 222 after retracting the needle. In Fig. 17, needle holder body 226, needle base 234, needle 236 and except the front end of spring 256 were forced into retraction cavity 244 by the expansion spring. Although the length and diameter and post-retraction position of the relaxed spring 256 may vary, needle 236 must remain inside barrel 202 following retraction, to protect against accidental needle sticks.
    [00068] Another embodiment of the medical device of the invention is described with reference to Figs. 18-23 of the drawings. With reference to these figures, the medical device 300, which can be, for example, a hypodermic needle, comprises the drum 302, a retractable needle unit, seated on the front of the drum 302, and the plunger 304 which is slidably inserted within an opening defined by the substantially tubular collar 342 at the rear of drum 302. Drum 302 further comprises a pair of opposing projecting, transverse flanges 326, 328 and a smaller nose section 336.
    [00069] The retractable needle unit is supported within the front of the drum 302 and further comprises needle holder 308, elastomeric retaining member 310, compressed spring 312. Retaining member 310 provides a fluid seal between the support of needle 308 and the inner wall of the drum 302. The end extending to the front of the compressed spring 312 is prevented from moving forward relative to the drum 302 by a rear-facing annular shoulder 331 of the nose section 336, which also fits in a forward facing annular shoulder arranged close to the front of the needle holder 308. The fluid flow path through the needle holder 308 is preferably arranged between the needle bore 314 and the transverse fluid flow path 332, which is disposed just in front of the rear tip 348 of the needle holder 308.
    [00070] The plunger 304 preferably comprises a substantially tubular wall defining a retraction cavity 330, the tubular wall having at least two circumferentially spaced ribs, extending axially 305, projecting radially outwardly to help maintain proper alignment between the plunger 304 and drum 302, leaving a smaller diameter section 318 of ribs 305. A larger diameter section 340 is desirably arranged at the rear of plunger 304, which is receptive within, or in close association with, the inner side of the rear collar 342 of the medical device 300. The tubular wall of the plunger 304 defines a retracting cavity extending longitudinally 330, which is closed at the rear end by the end cap 338 and at its front end by the generally transverse elastomeric film 317 of the plunger seal 316. The plunger seal 316 is seated over the small outer diameter section 328 of the plunger 304. An annular projection radially extending air 322, having an inclined front shoulder and a relatively square rear shoulder, or other similarly effective structure, is preferably provided to prevent the plunger seal from slipping off the front of the plunger 304 when the plunger 304 is pulled back into the drum 302, as can occur, for example, during suction of the medical device 300.
    [00071] The forward extending end 320 of the tubular wall 304 may have a part that extends further forward than the other, thereby causing at least a part of the elastomeric film 317 to be tilted slightly out of the plane transverse that is perpendicular to the common longitudinal geometric axis of the medical device 300. This also causes the part of the surface facing the front of the elastomeric film 317, which covers the part extending further ahead of the stepped front end 320 to contact the retaining member 310 of the retractable needle unit first, thereby initially concentrating the force of the user's thumb on one side of the retaining member 310 to initiate movement of the retaining member 310 in relation to the needle holder 308 and the inner wall of the drum 302 .
    [00072] With reference to Fig. 18, together with Fig. 21, when the plunger 304 is moved forward into the barrel 300, the elastomeric film 317 eventually contacts the projection 348 of the needle holder 308, causing that the elastomeric film 317 is stretched over the part extending behind the needle holder and extended backwards by a slight distance into the retraction cavity 330. When the plunger 304 continues to move forward, the shoulder ring facing the front of the plunger seal 316 contacts the shoulder by tapering inward 323 of the barrel 302 adjacent to the nose 336, thereby causing the plunger seal 316 to slide back over the small diameter section 318 of the plunger 304 to the position shown in Fig. 22. When this occurs, the front end 320 of the plunger 304 causes the retainer 310 to be pushed forward into the space 311 (Fig. 21) to the position shown in Fig. 22 When this occurs, the elastomeric film 317 breaks and the needle holder 308 is no longer forced against the force exerted by the compressed spring 312. As shown in Fig. 22 with reference also to Fig. 21, when the spring 312 expands, the support of needle 308 and needle 314 are driven back into the retraction cavity inside the plunger 304. When the medical device 300 is in the fully retracted position as shown in Fig. 22, all parts of the retractable needle unit are arranged inside the drum 302.
    [00073] The drum of the medical device of the invention can be made of plastic, glass or any other material suitable for the intended use. As used herein, the term "plastic" refers mainly to moldable thermoplastic polymers, such as, for example, polyethylene and polypropylene, which may also contain other ingredients such as dressings, fillers, reinforcing agents, colorants and / or plasticizers etc. . and that can be formed or molded under heat and pressure. Where the subject device is intended for use in applications where the drum may be in prolonged direct contact with therapeutic liquids, which may interact with the plastic or which may be degraded by substituents that may otherwise enter the liquid from the plastic, plastic should not be used. The tubular body or handle of the plunger of the invention is also preferably made of plastic and will typically not come into contact with a therapeutic liquid prior to retraction.
    [00074] In the past, elastomeric materials used to produce plunger seals have often included crosslinked thermosetting rubber polymers, which are easily deformable, but which are approved for use with pharmaceutical grade fluids and are not readily susceptible to leaching or migration of gas. It has now been observed that the plunger seal of the present invention can be made of an injection moldable elastomeric material, approved for use with the therapeutic fluids of interest which, when molded into the annular body part, are sufficiently rigid to provide a reliable liquid seal between the plunger cable and the drum and to resist disengagement of the plunger cable from the plunger seal when the plunger is removed, for example, during suction. Also, because the plunger seal is ideally unitarily molded from a single elastomeric material, the material used must be of sufficient thickness and hardness so that it can be stretched and sharpened before retraction, but not prematurely, and will also tear readily when penetrated by a rearward projection onto the needle retraction unit to allow retraction. An elastomer suitable for such use may be Uniprene® rubber, having a Shore A hardness of about 45. The material used to produce the retaining ring is preferably a crosslinked thermosetting rubber polymer, which is more easily deformable than plastic and which is approved for use with pharmaceutical grade fluids and which is not readily susceptible to leaching or gas migration.
    [00075] The needle holder part of the needle retraction unit can also be made of plastic or glass, the use of plastic being preferred. The needle holder can be made, for example, of polycarbonate or acrylonitrile-butadiene-styrene (“ABS”). Such polymeric resins and adhesives suitable for attaching a needle to the needle holder (or the needle tip, in the case of a device having a fixable, separable and / or exchangeable needle) are commercially available.
    [00076] As used herein, the term "fluid" refers primarily to liquids, but may also include suspensions of solids dispersed in liquids and gases dissolved in or otherwise present together within liquids, within the fluid containing parts of the devices of the invention. Conventional commercially available lubricants, suitable for use with plunger seals, can be used to further improve the seal and decrease the force that must be applied through the plunger, to employ the devices of the invention and to perform retraction.
    [00077] An advantage of the present invention is that when the tightly stretched and tightened elastomeric film 148 is broken, the rubbery material bounces backwards with sufficient speed and force, so that the resulting opening is large enough for the needle holder 118 and the front end of the spring 124 passes through without interruption which could otherwise prevent complete retraction of the needle 122 into the body 112. Another advantage of the present invention is that the thumb force required to initiate the retraction is substantially less than was previously obtainable in conventional, commercially available syringes with retractable needles. This is at least partly because the present invention has no plug that must be dislodged to gain access to the plunger cavity, partly because there is no cutting or breaking of plastic parts, which is required to initiate the retraction, and partly because there is no need for a two-piece plunger, which must be operated to start cutting or breaking. Based on preliminary tests, it is believed that the average thumb force required to retract the needle is reduced by more than thirty percent (30%), through the use of the structures and materials described here. It is believed that the sliding and stretching of the elastomeric film of the plunger seal, at the time of penetration by the needle holder, contributes to a reduction in the strength of the thumb, required to initiate the retraction.
    [00078] Another advantage of the present invention is that the use of a movable piston seal, with a unitary annular body, together with a transversal elastomeric film, allows the use of manufacturing tolerances that are larger and more compliant than those previously required to produce medical devices with plungers having internal retraction cavities, which are sealed by a removable plug prior to retraction. Also, with the devices of the present invention, premature shutdown due to the pressure exerted on the plug by a fluid contained in the device is not a restriction.
    [00079] Another operational advantage of the present invention is the smooth forward movement of the plunger to initiate retraction. This smooth release is directly attributable to the combined use of a sliding and breakable piston seal and an elastomeric retaining ring, which is pushed into the release position by continuous forward movement of the piston, without the shocks or bumps resulting from breaking parts plastic, displacement of plunger plugs or the audible “clicks” previously experienced in the use of syringes with retractable needles.
    [00080] Another embodiment of the invention is described with reference to Figs. 24-28, in which a differently configured elastomeric seal 350 is installed at the front of plunger 318. Generally speaking, the part of elastomeric film 358, which is stretched over the opening in front of plunger 318, is desirably thickened slightly in the area 360, where the elastomeric film 358 of the plunger seal 350 is contacted by the projection extending behind the needle holder as shown, for example, in Fig. 21, to reduce the likelihood of premature tearing of the film 358 prior to retraction . Also, an annular groove or groove 362 is desirably provided around the front parts 344, 346 of the plunger 318, to reduce the plunger force that is required to advance the plunger 318 into the barrel 302 and to obtain retraction of the needle by breaking the 358 elastomeric film.
    [00081] The elastomeric plunger seal 350 preferably comprises a unitary molded, elastomeric body, 350, having a substantially cylindrical side wall, having annular recesses facing inwards and outwards 354, 356, respectively. The annular groove 356 decreases frictional drag along the inner wall of the drum 302, while maintaining a fluid seal between the plunger 318 and the drum 302. The annular groove '354 allows the body of the plunger seal 350 to slide in relation to to the plunger 318, when the plunger 318 slides in relation to the barrel 302, as indicated by arrows 364, 352 in Figs. 25 and 24, respectively.
    [00082] With reference to Fig. 24, when the plunger 318 is moved backwards in relation to the drum 302, as indicated by the arrow 352 and as it would occur, for example, when pulling a fluid into the subject device, the seal body plunger 350 can slide forward until the annular flange protruding 322 from plunger 318 contact against the rear wall of the inward annular recess 354. Referring next to Fig. 25, when plunger 318 is moved to forward with respect to drum 302, as indicated by arrow 364 and as it would occur, for example, when expelling fluid from the subject device, frictional drag of the plunger seal 350 against the inner wall of drum 302 will cause seal 350 to slide backwards with respect to the annular flange 322 of the plunger 318, thereby stretching the elastomeric film 358 tighter through the opening in the front of the plunger 318, which provides access to the needle retraction cavity 330. showed that the force required to advance the plunger 318 forward inside the barrel 302 can be reduced substantially without increasing the probability of premature rupture of the part of elastomeric film 358, providing the annular groove or groove 362 in the part facing forward of the piston seal body 350, arranged around and slightly radially outwardly from the plunger fronts 344, 346 of the plunger 318. When the plunger 318 advances forward into the barrel 302, the substantially cylindrical body section of the plunger seal 350 slides backwards relative to plunger 318, opening a gap between the rear end of annular recess 354 and an annular flange 322 of plunger 318.
    [00083] Other changes and modifications of the invention will probably become evident to those of ordinary skill in the art, when reading this report, in view of the accompanying drawings, and it is intended that the scope of the invention described here is limited only by the broadest interpretation of the attached claims, to which inventors are legally qualified.
    权利要求:
    Claims (8)
    [0001]
    1. Medical device (10) having a drum (24), a retractable needle (20), a needle retraction unit (18, 22), and a plunger (12) that slidably fits with the drum (24), in that: the needle retraction unit (18, 22) is propelled to project the needle (20) backwards with respect to the drum (24), during the retraction of the needle (20), and is held in position in relation to the drum (24), before retracting the needle (20) at least in part by a retaining member (16) which contacts the drum (24); and the plunger (12) has a tubular plunger body (38) and an internal retraction cavity (40), configured to receive enough from the needle retraction unit (18, 22) to which the needle (20) is not exposed following retraction, the medical device (10) further comprises an elastomeric plunger seal (14) having an annular body disposed on the plunger (12), the plunger seal (14) further comprising a perforated transverse elastomeric film (58) , integrally formed with the annular body, which embraces and seals an opening within the retraction cavity (40) before or during the retraction of the needle (20); wherein the needle retraction unit (18, 20, 22, 16) comprises a structure projecting backwards (64) which is configured to contact, stretch and break the elastomeric film (58) according to the plunger (12). moved forward into the drum (24), where the plunger (12) contacts the retaining member (16) to release the needle retraction unit (18, 22) from the drum (24) as the plunger (12) is advanced inside the drum (24) characterized by the fact that the annular body is movable backwards in the piston (12), and in which the piston seal (14) comprises an annular recess (46) for receiving and sliding over a positioning ring ring (44) of the tubular body (38) of the plunger.
    [0002]
    Medical device (10) according to claim 1, characterized by the fact that the plunger seal (14) contacts the retaining member (16) to release the needle retraction unit (18, 22) from the drum (24) when the plunger (12) is advanced inside the drum (24).
    [0003]
    Medical device (10) according to claim 2, characterized in that a part of the perforated transverse elastomeric film (58) contacts and moves the retaining member (16) forward to release the needle retraction unit (18 , 22) of the drum (24), when the plunger (12) is advanced inside the drum (24).
    [0004]
    Medical device (10) according to claim 1, characterized in that the perforated transverse elastomeric film (58) is stretched when at least part of the annular body (14) moves backwards over the plunger (12).
    [0005]
    5. Medical device (10) according to claim 1, characterized by the fact that it is configured as a syringe.
    [0006]
    Medical device (10) according to claim 1, characterized by the fact that the needle retraction unit (18, 22) comprises a spring (22) that propels the retractable needle (20) towards the retraction cavity ( 40) and where the rearward projecting structure (64) pierces the perforated transverse elastomeric film (58) in such a way that the spring (22) can expand upwardly through the elastomeric film (58) during retraction.
    [0007]
    7. Medical device (10) according to claim 1, characterized by the fact that the needle (20) is reliably fixable to the needle retraction unit (18, 22) and can be changed during the use of the device or before retraction .
    [0008]
    8. Medical device (10) according to claim 1, characterized by the fact that the retaining member (16) is an elastomeric ring
    类似技术:
    公开号 | 公开日 | 专利标题
    BR112012033775B1|2020-07-28|MEDICAL DEVICE HAVING A DRUM, A RETRACTABLE NEEDLE, A NEEDLE RETRACTION UNIT AND A Piston
    ES2396687T3|2013-02-25|Retractable needle set for a syringe
    ES2230201T3|2005-05-01|HYPODERMIC SYRINGE WITH SELECTIVELY RETRACTABLE NEEDLE.
    US7147621B2|2006-12-12|Single use syringe
    US10765815B2|2020-09-08|Retractable needle syringe
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    US10709847B2|2020-07-14|Retractable needle syringe with unitary propellant release module
    RU2574368C2|2016-02-10|Medical device with retracted needle and movable piston seal
    OA16289A|2015-04-24|Medical device with retractable needle and moveable plunger seal.
    MXPA99002094A|1999-09-01|Pre-filled retractable needle injection devices
    同族专利:
    公开号 | 公开日
    CN102573966B|2016-05-04|
    BR112012033775A2|2017-05-02|
    JP6033220B2|2016-11-30|
    CA2802547A1|2012-01-05|
    AR082031A1|2012-11-07|
    JP2013530022A|2013-07-25|
    MX342121B|2016-09-14|
    US9642970B2|2017-05-09|
    WO2012003343A1|2012-01-05|
    EP2588174A4|2014-01-22|
    EP2588174B1|2020-02-26|
    US20170239426A1|2017-08-24|
    AU2011272832B2|2015-09-03|
    CN102573966A|2012-07-11|
    ES2776993T3|2020-08-03|
    ZA201209736B|2013-09-25|
    AP2013006670A0|2013-01-31|
    MX2012015110A|2013-04-24|
    TW201212966A|2012-04-01|
    US20120004621A1|2012-01-05|
    TWI616217B|2018-03-01|
    RU2013103801A|2014-08-10|
    CA2802547C|2018-05-22|
    CL2012003704A1|2013-03-22|
    KR101838876B1|2018-03-16|
    SG186367A1|2013-01-30|
    KR20130137121A|2013-12-16|
    PE20131076A1|2013-10-04|
    EP2588174A1|2013-05-08|
    CO6640321A2|2013-03-22|
    AU2011272832A1|2013-02-07|
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    EP3377155A4|2016-11-18|2019-08-28|Global Medisafe Holdings Ltd|Retractable syringe|
    EP3562534A1|2016-12-30|2019-11-06|Novo Nordisk A/S|A needle cannula, an injection needle assembly for an injection device and an injection device comprising such assembly|
    US20190298928A1|2018-03-29|2019-10-03|Thomas J. Shaw|Syringe with Flat Indicia Display Surface|
    JP2020533027A|2018-08-30|2020-11-19|ジアンスー ツァィナー メディカル カンパニー リミテッドＪｉａｎｇｓｕ Ｃａｉｎａ Ｍｅｄｉｃａｌ Ｃｏ．，Ｌｔｄ|Safety syringe|
    US20200268985A1|2019-02-27|2020-08-27|Retractable Technologies,Inc|Syringe with Multifunctional Needle Holder and Retainer Ring Assembly|
    CN110721368A|2019-10-19|2020-01-24|徐州宏华玻璃科技有限公司|Glass syringe suitable for injection|
    KR102219035B1|2020-12-11|2021-02-23|풍림파마텍|Disposable injection device with locking structure to prevent reuse|
    KR102224517B1|2020-12-11|2021-03-09|풍림파마텍|Disposable injection device with improved locking structure between outer housing and locking module to prevent reuse|
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    法律状态:
    2018-12-26| B06F| Objections, documents and/or translations needed after an examination request according art. 34 industrial property law|
    2019-09-17| B06U| Preliminary requirement: requests with searches performed by other patent offices: suspension of the patent application procedure|
    2020-05-19| B09A| Decision: intention to grant|
    2020-07-28| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 30/06/2011, OBSERVADAS AS CONDICOES LEGAIS. |
    优先权:
    申请号 | 申请日 | 专利标题
    US12/827548|2010-06-30|
    US12/827,548|US9642970B2|2010-06-30|2010-06-30|Syringe with retractable needle and moveable plunger seal|
    PCT/US2011/042628|WO2012003343A1|2010-06-30|2011-06-30|Medical device with retractable needle and moveable plunger seal|
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